Promonitor

Promonitor

Testing for drug bioavailability and immunogenicity includes IFX, Anti-IFX, ADL, Anti-ADL, RTX, Anti-RTX, ETN, Anti-ETN, GLM, Anti-GLM, VDZ, Anti-VDZ, UTK, and Anti-UTK. Personalize high-quality treatment of chronic inflammatory diseases with ease.

Main benefits

Optimized Therapy

Refine treatment of chronic inflammatory diseases with a individualized treatment for every patient enabling a personalized approach to therapy with biologics. Promonitor provides an early warning if the treatment regime may require modification.

Cost Effective

Reduce the use of ineffective treatment strategies, allowing a more efficient use of available resources. Effectively manage resources with the information provided by Promonitor.

Easy to use

Quickly generate easy to interpret results with ELISA-based tests and readily available equipment in 4 simple steps and 30 mins of hand-on time with precoated microplates and ready-to-use reagents.

Flexible

Expand lab operations and workflow with multiple tests and configurations and test both drug levels and anti-drug antibody levels in manual or automated modes.

High-quality

Results you can rely on with high specificity and sensitivity testing supported by a large number of peer-reviewed articles and referenced in over 100 publications.

Monitoring Biosimilars

Evaluation studies have demonstrated that Promonitor kits are able to quantify not only biological drug levels, but also biosimilar drugs.

Product specifications

Promonitor-IFX
Product Detail

Method
Specification

Quantitative capture ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars
Specification

Internal evaluation studies have demonstrated that Promonitor IFX is able to quantify levels for
the following biosimilars1,2:

  • CT-P13
  • SB2
  • GP1111

Standard
Specification

WHO 1° international standard for IFX (NIBSC: 16/170)

References/ISI

  • Ruiz-Argüello MB, Maguregui A, Ruiz Del Agua A, et al. Antibodies to infliximab in Remicade-treated rheumatic patients show identical reactivity towards biosimilars. Ann Rheum Dis. 2016;75(9):1693-1696.
  • Fiorino G, Ruiz-Argüello MB, Maguregui A, et al. Full interchangeability in regard to immunogenicity between the infliximab reference biologic and biosimilars CT-P13 and SB2 in inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):601-60

References/ISI

  • Ruiz-Argüello MB, Maguregui A, Ruiz Del Agua A, et al. Antibodies to infliximab in Remicade-treated rheumatic patients show identical reactivity towards biosimilars. Ann Rheum Dis. 2016;75(9):1693-1696.
  • Fiorino G, Ruiz-Argüello MB, Maguregui A, et al. Full interchangeability in regard to immunogenicity between the infliximab reference biologic and biosimilars CT-P13 and SB2 in inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):601-60
Product Detail Specification

Method

Quantitative capture ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars

Internal evaluation studies have demonstrated that Promonitor IFX is able to quantify levels for
the following biosimilars1,2:

  • CT-P13
  • SB2
  • GP1111

Standard

WHO 1° international standard for IFX (NIBSC: 16/170)

Promonitor-ANTI IFX
Product Detail

Method
Specification

Quantitative bridging ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars
Specification

Internal evaluation studies have demonstrated that Promonitor anti-IFX is able to quantify anti-drug antibodies levels for following biosimilars1

  • CT-P13
  •  SB2
     

References

Fiorino G, Ruiz-Argüello MB, Maguregui A, et al. Full interchangeability in regard to immunogenicity between the infliximab reference biologic and biosimilars CT-P13 and SB2 in inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):601-606.

References

Fiorino G, Ruiz-Argüello MB, Maguregui A, et al. Full interchangeability in regard to immunogenicity between the infliximab reference biologic and biosimilars CT-P13 and SB2 in inflammatory bowel disease. Inflamm Bowel Dis. 2018;24(3):601-606.
Product Detail Specification

Method

Quantitative bridging ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars

Internal evaluation studies have demonstrated that Promonitor anti-IFX is able to quantify anti-drug antibodies levels for following biosimilars1

  • CT-P13
  •  SB2
     

Promonitor-ADL
Product Detail

Method
Specification

Quantitative sandwich ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars
Specification

Internal evaluation studies have demonstrated that Promonitor ADL and Promonitor Anti-ADL are able to quantify the drug levels anti-drug antibodies levels for the following biosimilars1 :

  • ABP501
  • SB5
  • GP 2017

Standard
Specification

WHO 1° international standard for ADL (NIBSC code: 17/236)

References

  1.  Ruiz-Argüello MB, Maguregui A, Martinez A, Nagore D. P329 Adalimumab therapeutic drug monitoring test validated for measuring ABP 501 biosimilar. J Crohns Colitis. 2019;13(S1):S265-S266.

References

  1.  Ruiz-Argüello MB, Maguregui A, Martinez A, Nagore D. P329 Adalimumab therapeutic drug monitoring test validated for measuring ABP 501 biosimilar. J Crohns Colitis. 2019;13(S1):S265-S266.
Product Detail Specification

Method

Quantitative sandwich ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars

Internal evaluation studies have demonstrated that Promonitor ADL and Promonitor Anti-ADL are able to quantify the drug levels anti-drug antibodies levels for the following biosimilars1 :

  • ABP501
  • SB5
  • GP 2017

Standard

WHO 1° international standard for ADL (NIBSC code: 17/236)

Promonitor-ANTI ADL
Product Detail

Method
Specification

Quantitative bridging ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative bridging ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-RTX
Product Detail

Method
Specification

Quantitative sandwich ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars
Specification

Internal evaluation studies have demonstrated that the Promonitor RTX  kit is able to quantify drug levels for
the following biosimilars:

  • CT-P10 (Truxima/Blitzima/Ritemvia/Rituzema) 
Product Detail Specification

Method

Quantitative sandwich ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars

Internal evaluation studies have demonstrated that the Promonitor RTX  kit is able to quantify drug levels for
the following biosimilars:

  • CT-P10 (Truxima/Blitzima/Ritemvia/Rituzema) 

Promonitor-ANTI RTX
Product Detail

Method
Specification

Quantitative bridging ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative bridging ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-ETN
Product Detail

Method
Specification

Quantitative sandwich ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars
Specification

Internal evaluation studies have demonstrated that the Promonitor ETN kit is able to quantify drug levels for
the following biosimilars :

  •   SB4 (Benepali)
  •   GP2015 (Erelzi)
Product Detail Specification

Method

Quantitative sandwich ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars

Internal evaluation studies have demonstrated that the Promonitor ETN kit is able to quantify drug levels for
the following biosimilars :

  •   SB4 (Benepali)
  •   GP2015 (Erelzi)

Promonitor-ANTI ETN
Product Detail

Method
Specification

Quantitative sandwich ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars
Specification

Internal evaluation studies have demonstrated that the Promonitor ETN kit is able to quantify drug levels for
the following biosimilars :

  •   SB4 (Benepali)
  •   GP2015 (Erelzi)
Product Detail Specification

Method

Quantitative sandwich ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Biosimilars

Internal evaluation studies have demonstrated that the Promonitor ETN kit is able to quantify drug levels for
the following biosimilars :

  •   SB4 (Benepali)
  •   GP2015 (Erelzi)

Promonitor-GLM
Product Detail

Method
Specification

Quantitative capture ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative capture ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-ANTI GLM
Product Detail

Method
Specification

Quantitative capture ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative capture ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-VDZ
Product Detail

Method
Specification

Quantitative sandwich ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative sandwich ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-ANTI VDZ
Product Detail

Method
Specification

Quantitative bridging ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative bridging ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-UTK
Product Detail

Method
Specification

Quantitative sandwich ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative sandwich ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Promonitor-ANTI UTK
Product Detail

Method
Specification

Quantitative bridging ELISA

Microplate size
Specification

96 wells

Kit storage conditions
Specification

Refrigerated at 2-8°C

Sample
Specification

Serum

Serum storage conditions
Specification

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.

Product Detail Specification

Method

Quantitative bridging ELISA

Microplate size

96 wells

Kit storage conditions

Refrigerated at 2-8°C

Sample

Serum

Serum storage conditions

Sera can be stored or transported at RT (20-25°C) for up to 2 days. Alternatively, sera can be
stored at 2-8°C for up to 5 days; if serum will not be processed within 5 days, freeze it at -20°C or
lower. If frozen sera are used, mix thoroughly before analysis. Avoid repetitive freeze-thaw cycles.